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Expression of AC133 and CD117 on candidate normal stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia

Lookup NU author(s): Professor Josef Vormoor

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Abstract

To identify residual candidate normal progenitor/stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia (ALL), expression of AC133 and CD117 was analysed on the leukaemic cell clone and on immature B-lineage-negative CD34+CD19- bone marrow cells. 10/25 patients (40%) had no detectable expression of AC133 within the leukaemic cell clone. 24/26 patients (92%) lacked expression of CD117 on the leukaemic blast cell population. In contrast, a distinct AC133-positive cell population was found in 8/8 children with AC133-negative ALL and a CD117-positive cell population could be identified in 12/12 children with CD117-negative ALL, within the CD34+CD19- progenitor/stem cell compartment. These observations provide further evidence that in B-cell precursor ALL, unlike in acute myelogenous leukaemia, it may be possible to distinguish residual normal progenitor/stem cells from the leukaemic cell clone.

Publication metadata

Author(s): Baersch G, Baumann M, Ritter J, Jürgens H, Vormoor J

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 1999

Volume: 107

Issue: 3

Pages: 572-580

Print publication date: 01/12/1999

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

URL: http://dx.doi.org/10.1046/j.1365-2141.1999.01746.x

DOI: 10.1046/j.1365-2141.1999.01746.x

Notes: 0007-1048 (Print) Journal Article

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