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Lookup NU author(s): Professor Hermann Josef Vormoor
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To identify residual candidate normal progenitor/stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia (ALL), expression of AC133 and CD117 was analysed on the leukaemic cell clone and on immature B-lineage-negative CD34+CD19- bone marrow cells. 10/25 patients (40%) had no detectable expression of AC133 within the leukaemic cell clone. 24/26 patients (92%) lacked expression of CD117 on the leukaemic blast cell population. In contrast, a distinct AC133-positive cell population was found in 8/8 children with AC133-negative ALL and a CD117-positive cell population could be identified in 12/12 children with CD117-negative ALL, within the CD34+CD19- progenitor/stem cell compartment. These observations provide further evidence that in B-cell precursor ALL, unlike in acute myelogenous leukaemia, it may be possible to distinguish residual normal progenitor/stem cells from the leukaemic cell clone.
Author(s): Baersch G, Baumann M, Ritter J, Jürgens H, Vormoor J
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
Print publication date: 01/12/1999
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
Notes: 0007-1048 (Print)
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