Toggle Main Menu Toggle Search

Open Access padlockePrints

Expression of AC133 and CD117 on candidate normal stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia

Lookup NU author(s): Professor Hermann Josef Vormoor

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

To identify residual candidate normal progenitor/stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia (ALL), expression of AC133 and CD117 was analysed on the leukaemic cell clone and on immature B-lineage-negative CD34+CD19- bone marrow cells. 10/25 patients (40%) had no detectable expression of AC133 within the leukaemic cell clone. 24/26 patients (92%) lacked expression of CD117 on the leukaemic blast cell population. In contrast, a distinct AC133-positive cell population was found in 8/8 children with AC133-negative ALL and a CD117-positive cell population could be identified in 12/12 children with CD117-negative ALL, within the CD34+CD19- progenitor/stem cell compartment. These observations provide further evidence that in B-cell precursor ALL, unlike in acute myelogenous leukaemia, it may be possible to distinguish residual normal progenitor/stem cells from the leukaemic cell clone.


Publication metadata

Author(s): Baersch G, Baumann M, Ritter J, Jürgens H, Vormoor J

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 1999

Volume: 107

Issue: 3

Pages: 572-580

Print publication date: 01/12/1999

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

URL: http://dx.doi.org/10.1046/j.1365-2141.1999.01746.x

DOI: 10.1046/j.1365-2141.1999.01746.x

Notes: 0007-1048 (Print) Journal Article


Altmetrics

Altmetrics provided by Altmetric


Share