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Lookup NU author(s): Dr Sarah Charman
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Objective: Hypertriglyceridemic waist (HW) and waist-to-height ratio(WHTR) are simple clinical tools that identify adults at risk of cardiometabolic disorders and cardiovascular disease. Whether this applies in youth is under-researched and this study therefore investigated whether the HW phenotype and WHTR are associated with cardiometabolic disorders in children and adolescents. Methodology: This was a cross-sectional design study. Anthropometry, biochemical variables, and cardiorespiratory fitness were assessed in 234 participants (122 girls) aged 10–19 years from Bedfordshire, United Kingdom. The HW phenotype was defined as a waist circumference _90th percentile for age and sex, and triglyceride concentrations _1.24 mmol/l, and a high WHTR defined as >0.5. ANCOVA and logistic regression were used in the analysis. Results: In participants with the HW phenotype, clustered risk score was lower (P < 0.05), the odds of having high cardiorespiratory fitness (ml/kg/min) lower (0.045; 95% CI 0.01, 0.42), and the odds of having low HDL-cholesterol (4.41; 1.50, 12.91), impaired fasting glucose (3.37; 1.06, 10.72), and _1 (4.78; 1.32, 17.29) and _2 risk factors (7.16; 2.38, 21.54) higher than those without the phenotype. Those with a high WHTR had lower clustered risk (P < 0.05), higher odds of having low HDL-cholesterol (2.57; 1.11, 5.95), high diastolic blood pressure (3.21; 1.25, 8.25), and _2 risk factors (5.57; 2.05, 15.17) than those with normal WHTR. Conclusion: The HW phenotype may be a better simple marker than WHTR for identifying children and adolescents at risk for cardiometabolic disorders.
Author(s): Bailey DP, Savory LA, Denton SJ, Davies BR, Kerr CJ
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: 5th International Congress on Prediabetes and Metabolic Syndrome
Year of Conference: 2013