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Dr Max RobinsonORCiD
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Small cell carcinoma/neuroendocrine carcinoma (SCNEC) of the oropharynx is uncommon. Recently, an association has been reported between oropharyngeal SCNEC and high-risk human papillomavirus (HPV) infection. While HPV infection confers a better prognosis for oropharyngeal squamous cell carcinoma, HPV infection does not appear to influence the biological behaviour of SCNECs, which are generally associated with poor clinical outcomes. We document two cases of SCNEC arising in the oropharynx with evidence of high-risk HPV infection. The cases highlight the expanding range of malignant oropharyngeal neoplasms that harbour oncogenic HPV infection and support the concept that, irrespective of HPV infection, neuroendocrine differentiation portends a poor prognosis.
Author(s): Bates T, McQueen A, Iqbal MS, Kelly C, Robinson M
Publication type: Article
Publication status: Published
Journal: Head and Neck Pathology
Print publication date: 01/03/2014
Online publication date: 10/07/2013
Acceptance date: 27/06/2013
ISSN (print): 1936-055X
ISSN (electronic): 1936-0568
Publisher: Springer US
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