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Malignant stem cells in childhood acute lymphoblastic leukemia: The stem cell concept revisited

Lookup NU author(s): Professor Hermann Josef Vormoor

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Abstract

We have recently shown that in childhood acute lymphoblastic leukemia (ALL) blasts at different stages of immunophenotypic maturation possess stem cell properties. Here, we discuss our results in the context of previous investigations of ALL stem cells and recent studies highlighting specific limitations of the xenotransplantation models for human hematopoietic cells. Leukemia-propagating stem cells in ALL may be more frequent than previously thought!

Publication metadata

Author(s): Vormoor HJ

Publication type: Review

Publication status: Published

Journal: Cell Cycle

Year: 2009

Volume: 8

Issue: 7

Pages: 996-999

Online publication date: 01/04/2009

Acceptance date: 28/01/2009

ISSN (print): 1538-4101

ISSN (electronic): 1551-4005

Publisher: Landes Bioscience

URL: http://dx.doi.org/10.4161/cc.8.7.7984

DOI: 10.4161/cc.8.7.7984

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