Browse by author
Lookup NU author(s): Dr Karine Macritchie, Dr Peter GallagherORCiD, Dr Adrian Lloyd, Dr Kamini Vasudev, Emeritus Professor Nicol Ferrier, Dr Peter Moore, Professor Allan Young
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
BACKGROUND: Bipolar disorder is associated with both white matter abnormalities and hypothalamo-pituitary-adrenal axis dysfunction. In a post-hoc analysis of diffusion tensor data, the relationship between cortisol levels and white matter structural integrity was explored in healthy controls and in euthymic patients with bipolar disorder.METHODS: Healthy control subjects and patients with bipolar disorder, prospectively verified as euthymic, underwent diffusion tensor MRI: fractional anisotropy and mean diffusivity data in fifteen regions of interest were obtained. Morning and evening salivary cortisol levels (SCLs) were measured.RESULTS: Significant negative partial correlations were found between fractional anisotropy and evening SCLs in control subjects in four periventricular regions. This pattern was absent in bipolar patients, possibly due to the presence of an excess of extracellular fluid manifested as a significant increase in mean diffusivity in those regions.LIMITATIONS: This is an exploratory, post-hoc analysis of data with relatively small sample sizes. Lithium treatment and past substance abuse in the bipolar group are potentially confounding factors in this study.CONCLUSIONS: These preliminary data show an inverse relationship between evening cortisol levels and a measure of periventricular white matter integrity in healthy controls. This relationship appears disrupted in bipolar patients, possibly due to periventricular osmoregulatory dysfunction, the effects of medication or past substance use. Future research should further investigate the influences of cortisol on oligodendrocyte function, white matter integrity and brain osmoregulation in bipolar disorder.
Author(s): Macritchie KAN, Gallagher P, Lloyd AJ, Bastin ME, Eyre R, Vasudev K, Marshall I, Wardlaw JM, Ferrier IN, Moore PB, Young AH
Publication type: Article
Publication status: Published
Journal: Journal of Affective Disorders
Year: 2013
Volume: 148
Issue: 2-3
Pages: 249-255
Print publication date: 01/06/2013
ISSN (print): 0165-0327
ISSN (electronic): 1573-2517
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/j.jad.2012.12.002
DOI: 10.1016/j.jad.2012.12.002
PubMed id: 23399478
Altmetrics provided by Altmetric