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Impact of the 7-valent pneumococcal conjugate vaccine on the incidence of childhood pneumonia

Lookup NU author(s): Dr Mohamed Elemraid, Professor Stephen Rushton, Dr Mark ShirleyORCiD, Dr Matthew Thomas, Dr David Spencer, Dr Fiona Hampton, Dr Kenneth Pollard, Professor Andrew GenneryORCiD, Dr Clark Clark



In September 2006, the 7-valent pneumococcal conjugate vaccine (PCV7) was added to the UK immunization programme. We aimed to evaluate the impact of PCV7 on the incidence of all-cause community-acquired pneumonia (CAP) in children. A prospective survey was undertaken in 2008-2009 at 11 hospitals in North East England of children aged 0-16 years with radiologically confirmed pneumonia. Data were compared to those from a similar survey undertaken in the same hospitals in 2001-2002. A total of 542 children were enrolled, of which 74% were aged < 5 years. PCV7 uptake was 90.7%. The incidence of pneumonia was 11.8/10000 [95% confidence interval (CI) 10.9-12.9], and the hospitalization rate was 9.9/10000 (95% CI 9.0-10.9). Compared to 2001, there was a 19% (95% CI 8-29) reduction in the rate of CAP in those aged < 5 years, and in those < 2 years a 33.1% (95% CI 20-45) reduction in the incidence of CAP and 38.1% (95% CI 24-50) reduction in hospitalization rates. However, for those unvaccinated aged >= 5 years, there was no difference in the incidence of CAP and hospitalization rate between both surveys. Since 2001, the overall reduction in incidence was 17.7% (95% CI 8-26) and for hospitalization 18.5% (95% CI 8-28). For the < 5 years age group there was a lower incidence of CAP in PCV7-vaccinated children (25.2/10000, 95% CI 22.6-28.2) than in those that were not vaccinated (37.4/10000, 95% CI 29.2-47.1). In conclusion, PCV7 has reduced both incidence and rate of hospitalization of pneumonia in children, particularly in the < 2 years age group.

Publication metadata

Author(s): Elemraid MA, Rushton SP, Shirley MDF, Thomas MF, Spencer DA, Eastham KM, Hampton F, Gorton R, Pollard K, Gennery AR, Clark JE, North East of England Paediatric Respiratory Infection Study Group

Publication type: Article

Publication status: Published

Journal: Epidemiology and Infection

Year: 2013

Volume: 141

Issue: 8

Pages: 1697-1704

Print publication date: 19/10/2012

Date deposited: 25/02/2014

ISSN (print): 0950-2688

ISSN (electronic): 1469-4409

Publisher: Cambridge University Press


DOI: 10.1017/S0950268812002257


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