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Acute myelogenous leukaemia in children under 2 years: Experiences of the West German AML studies BFM-78, -83 and -87

Lookup NU author(s): Professor Hermann Josef Vormoor


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Clinical, morphological, immunological, cytogenetical and prognostic features of 84 children under 2 years of age with AML in studies AML-BFM-78, -83 and -87 were retrospectively analysed. There was a high incidence of acute monoblastic leukaemia (FAB M5) (41 patients--49%) and acute megakaryoblastic leukaemia (FAB M7) (study AML-BFM-87: five patients--13%) in this age group. Acute monoblastic leukaemia was associated with hepatosplenomegaly, extramedullary organ manifestations and chromosomal abnormalities involving 11q23. The probability of an 11-year event-free survival of all patients under 2 years of the three studies combined was 39% (SD 6%). While the event-free survival rates of patients aged 2 years and older could be improved in studies AML-BFM-83 and -87 compared with study AML-BFM-78, overall prognosis in children under 2 years in the three consecutive studies remained unchanged. The event-free survival rate of children with acute monoblastic leukaemia in both age groups was comparable (7 yr-EFS (AML-BFM-83 and -87): much less than 2 years--43% (SD 9%), =/much greater than 2 years--33% (SD 9%); P much greater than 0.5). This also applied to other risk groups. In conclusion, taking the high incidence of acute monoblastic and megakaryoblastic leukaemia in children under 2 years into account, no significant differences between children under 2 years or older children concerning response to therapy and overall prognosis could be evaluated.

Publication metadata

Author(s): Vormoor J, Ritter J, Creutzig U, Boos J, Heyen P, Ludwig WD, Harbott J, Loffler H, Schellong G, Neidhardt M, Gnekow A, Henze G, Spaar HJ, Lieber P, Jacobi M, Rodeck H, Andler W, Gobel U, Jurgens H

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1992

Volume: 66

Issue: Suppl. 18

Pages: S63-S67

Print publication date: 01/08/1992

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827


PubMed id: 1503929

Notes: 0306-9443 (Print) Clinical Trial Journal Article