Browse by author
Lookup NU author(s): Dr Mohammed Shoaib
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The reinforcing effects of addictive drugs are thought to be more robust when the onset of the drug's effects is fast. It is unclear whether this concept extends to intravenous self-administration (IVSA) of nicotine. We therefore sought to examine the effects of infusion duration on nicotine IVSA in rats. Male Lister hooded rats (n=8) were given daily 1 h limited access to fixed ratio-3 nicotine IVSA (0.03 mg/kg/infusion). Once nicotine IVSA was established, the effect of infusion duration on nicotine seeking was evaluated at a constant unit dose and volume (0.5, 5.0, and 19.6 s compared with the 1-s training infusion duration). Active responses were significantly reduced when the infusion duration was increased (i.e. 5 or 19.6 s compared with 0.5 and 1 s), and the effect was qualitatively similar to saline substitution. The likelihood of maintaining a reliable IVSA in rats was reduced by increasing the infusion duration. The infusion duration therefore represents an important determinant of nicotine reinforcement in rats.
Author(s): Wing VC, Shoaib M
Publication type: Article
Publication status: Published
Journal: Behavioural Pharmacology
Year: 2013
Volume: 24
Issue: 5-6
Pages: 517-522
Print publication date: 01/09/2013
ISSN (print): 0955-8810
ISSN (electronic): 1473-5849
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1097/FBP.0b013e3283644d58
DOI: 10.1097/FBP.0b013e3283644d58
Altmetrics provided by Altmetric
