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Genetics of Cisplatin Ototoxicity: Confirming the Unexplained?

Lookup NU author(s): Professor Alan Boddy

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Abstract

Replication of findings in clinical pharmacogenetic studies is essential but often neglected. The observation that TPMT and COMT genotypes, in combination with ABCC3 genotype, are predictive of ototoxicity following cisplatin treatment has been confirmed. However, translating this observation into a useful preventive strategy requires more mechanistic insight.

Publication metadata

Author(s): Boddy AV

Publication type: Editorial

Publication status: Published

Journal: Clinical Pharmacology & Therapeutics

Year: 2013

Volume: 94

Issue: 2

Pages: 198-200

Print publication date: 01/08/2013

ISSN (print): 0009-9236

ISSN (electronic): 1532-6535

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/clpt.2013.116

DOI: 10.1038/clpt.2013.116

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