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Lookup NU author(s): Professor Alan Boddy
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Replication of findings in clinical pharmacogenetic studies is essential but often neglected. The observation that TPMT and COMT genotypes, in combination with ABCC3 genotype, are predictive of ototoxicity following cisplatin treatment has been confirmed. However, translating this observation into a useful preventive strategy requires more mechanistic insight.
Author(s): Boddy AV
Publication type: Editorial
Publication status: Published
Journal: Clinical Pharmacology & Therapeutics
Print publication date: 01/08/2013
ISSN (print): 0009-9236
ISSN (electronic): 1532-6535
Publisher: Nature Publishing Group