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Lookup NU author(s): Dr Imad Malki
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Cutaneous fatty acid–binding protein (C-FABP), a cancer promoter and metastasis inducer, is overexpressed in the majority of prostatic carcinomas. Investigation of molecular mechanisms involved in tumor-promoting activity of C-FABP has established that there is a fatty acid–initiated signaling pathway leading to malignant progression of prostatic cancer cells. Increased C-FABP expression plays an important role in this novel signaling pathway. Thus, when C-FABP expression is increased, excessive amounts of fatty acids are transported into the nucleus where they act as signaling molecules to stimulate their nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ). The activated PPARγ then modulates the expression of its downstream target regulatory genes, which eventually lead to enhanced tumor expansion and aggressiveness caused by an overgrowth of cells with reduced apoptosis and an increased angiogenesis.
Author(s): Bao ZZ, Malki MI, Forootan S, Adamson J, Forootan F, Chen D, Foster C, Rudland F, Ke Y
Publication type: Article
Publication status: Published
Journal: Genes & Cancer
Print publication date: 18/09/2013
Date deposited: 20/09/2013
ISSN (print): 1947-6019
ISSN (electronic): 1947-6027
Publisher: Sage Publications, Inc.
Notes: First two authors contributed equally to this work
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