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A Novel Cutaneous Fatty Acid–Binding Protein-Related Signaling Pathway Leading to Malignant Progression in Prostate Cancer Cells

Lookup NU author(s): Dr Imad Malki

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Abstract

Cutaneous fatty acid–binding protein (C-FABP), a cancer promoter and metastasis inducer, is overexpressed in the majority of prostatic carcinomas. Investigation of molecular mechanisms involved in tumor-promoting activity of C-FABP has established that there is a fatty acid–initiated signaling pathway leading to malignant progression of prostatic cancer cells. Increased C-FABP expression plays an important role in this novel signaling pathway. Thus, when C-FABP expression is increased, excessive amounts of fatty acids are transported into the nucleus where they act as signaling molecules to stimulate their nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ). The activated PPARγ then modulates the expression of its downstream target regulatory genes, which eventually lead to enhanced tumor expansion and aggressiveness caused by an overgrowth of cells with reduced apoptosis and an increased angiogenesis.


Publication metadata

Author(s): Bao ZZ, Malki MI, Forootan S, Adamson J, Forootan F, Chen D, Foster C, Rudland F, Ke Y

Publication type: Article

Publication status: Published

Journal: Genes & Cancer

Year: 2013

Volume: 4

Issue: 7-8

Pages: 297-314

Print publication date: 18/09/2013

Date deposited: 20/09/2013

ISSN (print): 1947-6019

ISSN (electronic): 1947-6027

Publisher: Sage Publications, Inc.

URL: http://dx.doi.org/10.1177/1947601913499155

DOI: 10.1177/1947601913499155

Notes: First two authors contributed equally to this work


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