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Templation-induced re-equilibration in polymer-scaffolded dynamic combinatorial libraries leads to enhancements in binding affinities

Lookup NU author(s): Clare Mahon, Professor David Fulton

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Abstract

Addition of macromolecular templates to Polymer-Scaffolded Dynamic Combinatorial Libraries (PS-DCLs) constructed by the reversible conjugation of acylhydrazides onto aldehyde-functionalised polymer scaffolds has been shown to generate a population of polymers with enhanced binding affinities towards templates, as determined by a fluorescence-based method. The templating process, which harnesses electrostatic interactions between library members and templates, has been shown to be reversible, with PS-DCLs returning to their initial composition upon removal of the template. Solid-supported templates have been employed for the convenient isolation of the best-binding fraction of the library.

Publication metadata

Author(s): Mahon CS, Fulton DA

Publication type: Article

Publication status: Published

Journal: Chemical Science

Year: 2013

Volume: 4

Pages: 3661-3666

Print publication date: 03/07/2013

ISSN (print): 2041-6520

ISSN (electronic): 2041-6539

Publisher: RSC Publications

URL: http://dx.doi.org/10.1039/C3SC51413G

DOI: 10.1039/C3SC51413G

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