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Mitochondria, Prostate Cancer, and Biopsy Sampling Error

Lookup NU author(s): Dr Andrew Harbottle


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Mitochondria and their associated genome are emerging as sophisticated indicators of prostate cancer (PCa) biology. Alterations in the mitochondrial genome (mtgenome) have been implicated in cell proliferation, metastatic behavior, androgen independence, as a signal for apoptosis, and as a predictor of biochemical recurrence. Somatic mutation patterns in complete mtgenomes are associated with prostate specific antigen levels (PSA) in PCa patients and a large-scale mtgenome deletion (3.4kb) is consistent with a prostate "cancerization" field effect. This review will focus on the biological characteristics of mitochondria and their direct clinical application to PCa. Mitochondrial science is currently influencing clinical PCa diagnostics and the rapid progress in this area indicates future, break-through contributions in the general field of oncology.

Publication metadata

Author(s): Parr R, Mills J, Harbottle A, Creed J, Crewdson G, Reguly B, Guimont F

Publication type: Article

Publication status: Published

Journal: Discovery Medicine

Year: 2013

Issue: 83

Pages: 213-220

Print publication date: 25/04/2013

ISSN (print): 1539-6509

ISSN (electronic): 1944-7930

Publisher: Discovery Medicine