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A new 20-membered macrolide produced by a marine-derived Micromonospora strain

Lookup NU author(s): Professor Alan Bull, Professor Michael Goodfellow


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A new 20-membered macrolide named as levantilide C was isolated from the Micromonospora strain FIM07-0019 recovered from shallow coastal waters near the island of Chiloe, Chile. The chemical structure of levantilide C was elucidated on the basis of one- and two-dimensional NMR analysis. Two known indole derivatives were also isolated from this strain. Levantilide C exhibited moderate antiproliferative activity against several tumour cell lines.

Publication metadata

Author(s): Peng F, Wang CX, Xie Y, Jiang HL, Chen LJ, Uribe P, Bull AT, Goodfellow M, Jiang H, Lian YY

Publication type: Article

Publication status: Published

Journal: Natural Product Research

Year: 2013

Volume: 27

Issue: 15

Pages: 1366-1371

Print publication date: 16/11/2012

ISSN (print): 1478-6419

ISSN (electronic): 1478-6427

Publisher: Taylor & Francis


DOI: 10.1080/14786419.2012.740038


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Funder referenceFunder name
Leverhulme Trust
2010ZX09401-403National Significant Science and Technology Major Project for novel medicinal research
2011R1010-4Fujian Public Research Institute Special Foundation
2012ZX09301002-003National Significant Science and Technology Major Project for novel medicinal research