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Lookup NU author(s): Dr Ahmad Khundakar
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In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis.
Author(s): deFoubert G, Khundakar AA, Zetterström TS
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Print publication date: 11/10/2013
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
PubMed id: 23981663
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