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Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival

Lookup NU author(s): Dr Ahmad Khundakar


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In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis.

Publication metadata

Author(s): deFoubert G, Khundakar AA, Zetterström TS

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2013

Volume: 553

Pages: 211-215

Print publication date: 11/10/2013

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier


DOI: 10.1016/j.neulet.2013.08.029

PubMed id: 23981663


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