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Characterization of PTPN2 and its use as a biomarker

Lookup NU author(s): Dr Diego Miranda Saavedra

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Abstract

For years, the two main isoforms of PTPN2 have been an interesting yet academic topic of debate for researchers working on this phosphatase. In recent years, several studies were published in which these isoforms were attributed specific functions. Most importantly, differences in their stoichiometry have been reported to be associated with certain diseases such as inflammatory bowel diseases (IBDs). Hence, understanding the evolutionary ontogeny of the main transcripts and the physiological consequences of their expression have now become clinically relevant issues. Herein we describe the genomic controls placed upon PTPN2, the identified splice variants, the encoded PTPN2 proteins, and both the known and putative post-translational modifications that have been reported. Moreover, we examine the expression of PTPN2 isoforms in specific tissues as well as in a disease setting. PTPN2 is an important negative regulator of inflammation. Therefore, the following protocols are effective approaches for its adequate monitoring in inflammatory diseases’ progression and outcome.

Publication metadata

Author(s): Bussières-Marmen S, Hutchins AP, Tiganis T, Fiocchi C, Miranda-Saavedra D, Tremblay ML

Publication type: Article

Publication status: Published

Journal: Methods

Year: 2014

Volume: 65

Issue: 2

Pages: 239-246

Print publication date: 15/01/2014

ISSN (print): 1046-2023

ISSN (electronic): 1095-9130

Publisher: Academic Press

URL: http://dx.doi.org/10.1016/j.ymeth.2013.08.020

DOI: 10.1016/j.ymeth.2013.08.020

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