Toggle Main Menu Toggle Search

Open Access padlockePrints

Perspectives for integrating human and environmental risk assessment and synergies with socio-economic analysis

Lookup NU author(s): Professor Lynn FrewerORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


For more than a decade, the integration of human and environmental risk assessment (RA) has become an attractive vision. At the same time, existing European regulations of chemical substances such as REACH (EC Regulation No. 1907/2006), the Plant Protection Products Regulation (EC regulation 1107/2009) and Biocide Regulation (EC Regulation 528/2012) continue to ask for sector-specific RAs, each of which have their individual information requirements regarding exposure and hazard data, and also use different methodologies for the ultimate risk quantification. In response to this difference between the vision for integration and the current scientific and regulatory practice, the present paper outlines five medium-term opportunities for integrating human and environmental RA, followed by detailed discussions of the associated major components and their state of the art. Current hazard assessment approaches are analyzed in terms of data availability and quality, and covering non-test tools, the integrated testing strategy (ITS) approach, the adverse outcome pathway (AOP) concept, methods for assessing uncertainty, and the issue of explicitly treating mixture toxicity. With respect to exposure, opportunities for integrating exposure assessment are discussed, taking into account the uncertainty, standardization and validation of exposure modeling as well as the availability of exposure data. A further focus is on ways to complement RA by a socio-economic assessment (SEA) in order to better inform about risk management options. In this way, the present analysis, developed as part of the EU FP7 project HEROIC, may contribute to paving the way for integrating, where useful and possible, human and environmental RA in a manner suitable for its coupling with SEA.

Publication metadata

Author(s): Pery ARR, Schuurmann G, Ciffroy P, Faust M, Backhaus T, Aicher L, Mombelli E, Tebby C, Cronin MTD, Tissot S, Andres S, Brignon JM, Frewer L, Georgiou S, Mattas K, Vergnaud JC, Peijnenburg W, Capri E, Marchis A, Wilks MF

Publication type: Article

Publication status: Published

Journal: Science of Total Environment

Year: 2013

Volume: 456-457

Pages: 307-316

Print publication date: 24/06/2013

ISSN (print): 0048-9697

ISSN (electronic): 1879-1026

Publisher: Elsevier


DOI: 10.1016/j.scitotenv.2013.03.099


Altmetrics provided by Altmetric


Funder referenceFunder name
FP7-282896European Commission through the Project HEROIC