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Metabolic adaptations induced by high intensity interval training in hyperglycemic and hypercholesterolaemic sedentary women

Lookup NU author(s): Dr Carlos Celis Morales


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BACKGROUND: Besides the high level of physical inactivity in Chile, 10% and 38% of women are diabetic and hypercholesterolaemic, respectively. High intensity training could be an effective way of improving health on individuals at high metabolic risk.AIM: To investigate the effects of a high intensity training intervention on metabolic-related markers in sedentary women at high metabolic risk.Material and METHODS: Forty six overweight (BMI >25 kg/m2), sedentary women were assigned to four groups, according to their metabolic profile;hyperglycemic (H, n= 12), hyperglycemic/hypercholesterolemic (HH, n= 13), normoglycemic (N, n= 10) and normoglycemic/hypercholesterolemic (NH, n= 11). For 12 weeks, 5 days / week, subjects performed seven intervals of high intensity training (20 to 30 seconds) during a training session of 20 minutes. Anthropometric (body weight, BMI, waist circumference) and metabolic variables (glucose, total cholesterol, LDL, HDL and TG) were measured at baseline, 6 and 12 weeks of intervention.RESULTS: BMI and waist circumference were significantly reduced after 12 weeks of intervention. Similarly, glucose was significantly reduced after 12 weeks of intervention across all groups. Reduction was greatest in those groups with hyperglycemia (H = -16%, HH= -22%, N= -7.5%, NH= -9.6%). However, lipid profile (TG, total cholesterol, LDL and HDL) was only significantly reduced in the hypercholesterolemic groups.CONCLUSIONS: Physical activity programs incorporating high intensity training can improve glucose and lipid metabolism in subjects with metabolic disorders. Moreover, this benefit is greatest in those individuals with highest metabolic burden. This intervention program may be an alternative therapy for high metabolic risk individuals.

Publication metadata

Author(s): Álvarez C, Ramírez R, Flores M, Henríquez C, Campos C, Carrasco V, Martínez C, Celis-Morales C

Publication type: Article

Publication status: Published

Journal: Revista Medica de Chile

Year: 2013

Volume: 141

Issue: 10

Pages: 1293-1299

Print publication date: 01/10/2013

ISSN (print): 0034-9887

ISSN (electronic): 0717-6163

Publisher: Sociedad Medica de Santiago


DOI: 10.4067/S0034-98872013001000008


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