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Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage

Lookup NU author(s): Dr Amanda Villalvilla Garcia, Dr Rodolfo Gomez

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Abstract

Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.


Publication metadata

Author(s): Villalvilla A, Gomez R, Largo R, Herrero-Beaumont G

Publication type: Review

Publication status: Published

Journal: International Journal of Molecular Sciences

Year: 2013

Volume: 14

Issue: 10

Pages: 20793-20808

Print publication date: 16/10/2013

ISSN (electronic): 1422-0067

Publisher: MDPI AG

URL: http://dx.doi.org/10.3390/ijms141020793

DOI: 10.3390/ijms141020793


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