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Lookup NU author(s): Dr Janet Berrington,
Dr Christopher Stewart,
Professor Nicholas EmbletonORCiD
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Objective: Establish howneutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT). Methods: A total of 38preterm infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curveswere generated for CD64 counts at various threshold values. Results: PRU curves reduced the residual uncertainty of the presence of infection by up to 64%. Conclusions: The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.
Author(s): Berrington JE, Hearn RI, Hall C, Stewart CJ, Cummings SP, Embleton ND
Publication type: Article
Publication status: Published
Journal: Fetal & Pediatric Pathology
Print publication date: 01/02/2014
ISSN (print): 1551-3815
ISSN (electronic): 1551-3823
Publisher: Informa Healthcare
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