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Proportionate Reduction in Uncertainty of Late Onset Infection in Pre-term Infants by Neutrophil CD64 Measurement

Lookup NU author(s): Dr Janet Berrington, Dr Christopher StewartORCiD, Professor Nicholas EmbletonORCiD


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Objective: Establish howneutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT). Methods: A total of 38preterm infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curveswere generated for CD64 counts at various threshold values. Results: PRU curves reduced the residual uncertainty of the presence of infection by up to 64%. Conclusions: The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.

Publication metadata

Author(s): Berrington JE, Hearn RI, Hall C, Stewart CJ, Cummings SP, Embleton ND

Publication type: Article

Publication status: Published

Journal: Fetal & Pediatric Pathology

Year: 2014

Volume: 33

Issue: 1

Pages: 16-22

Print publication date: 01/02/2014

ISSN (print): 1551-3815

ISSN (electronic): 1551-3823

Publisher: Informa Healthcare


DOI: 10.3109/15513815.2013.842270


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