Toggle Main Menu Toggle Search

Open Access padlockePrints

Salivary Cytokines in Healthy Adolescent Girls: Intercorrelations, Stability, and Associations with Serum Cytokines, Age and Pubertal Stage

Lookup NU author(s): Dr Katrin Jaedicke


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Theoretically, the measurement of cytokines in saliva may have utility for studies of brain, behavior, and immunity in youth. Cytokines in saliva and serum were analyzed across three annual assessments in healthy adolescent girls (N = 114, 11–17 years at enrollment). Samples were assayed for GM-CSF, IFNγ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNFα, adiponectin, and cotinine. Results revealed: (1) cytokine levels, except IFNγ and IL-10, were detectable in saliva, and salivary levels, except IL-8 and IL-1β, were lower than serum levels; (2) salivary cytokine levels were lower in older girls and positively associated with adiponectin; (3) compared to serum levels, the correlations between salivary cytokines were higher, but salivary cytokines were less stable across years; and (4) except for IL-1β, there were no significant serum–saliva associations. Variation in basal salivary cytokine levels in healthy adolescent girls reflect compartmentalized activity of the oral mucosal immune system, rather than systemic cytokine activity

Publication metadata

Author(s): Riis JL, Out D, Dorn LD, Beal SJ, Denson LA, Pabst S, Jaedicke KM, Granger DA

Publication type: Article

Publication status: Published

Journal: Developmental Psychobiology

Year: 2013

Volume: 56

Issue: 4

Pages: 797-811

Print publication date: 19/07/2013

ISSN (print): 0012-1630

ISSN (electronic): 1098-2302

Publisher: Jossey Bass


DOI: 10.1002/dev.21149


Altmetrics provided by Altmetric