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Lookup NU author(s): Dr Katrin Jaedicke
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Theoretically, the measurement of cytokines in saliva may have utility for studies of brain, behavior, and immunity in youth. Cytokines in saliva and serum were analyzed across three annual assessments in healthy adolescent girls (N = 114, 11–17 years at enrollment). Samples were assayed for GM-CSF, IFNγ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNFα, adiponectin, and cotinine. Results revealed: (1) cytokine levels, except IFNγ and IL-10, were detectable in saliva, and salivary levels, except IL-8 and IL-1β, were lower than serum levels; (2) salivary cytokine levels were lower in older girls and positively associated with adiponectin; (3) compared to serum levels, the correlations between salivary cytokines were higher, but salivary cytokines were less stable across years; and (4) except for IL-1β, there were no significant serum–saliva associations. Variation in basal salivary cytokine levels in healthy adolescent girls reflect compartmentalized activity of the oral mucosal immune system, rather than systemic cytokine activity
Author(s): Riis JL, Out D, Dorn LD, Beal SJ, Denson LA, Pabst S, Jaedicke KM, Granger DA
Publication type: Article
Publication status: Published
Journal: Developmental Psychobiology
Year: 2013
Volume: 56
Issue: 4
Pages: 797-811
Print publication date: 19/07/2013
ISSN (print): 0012-1630
ISSN (electronic): 1098-2302
Publisher: Jossey Bass
URL: http://dx.doi.org/10.1002/dev.21149
DOI: 10.1002/dev.21149
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