Toggle Main Menu Toggle Search

Open Access padlockePrints

Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development

Lookup NU author(s): Alla Narytnyk, Kevin Gillinder, Dr Bernard Verdon, Dr Oliver Clewes, Professor Maya Sieber-Blum



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of neural crest cells and also a prerequisite for hair follicle induction prior to hair placode formation in the epidermis. As neural crest stem cells invade the epidermis during early embryonic development we aimed at determining whether neural crest cells affect hair follicle development. To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. Both, hair density and hair thickness were reduced in mutant mice. Furthermore, hair development was delayed and the relative ratio of hair types was affected. There was a decrease in zig-zag hairs and an increase in awl hairs. Mouse neural crest stem cells expressed ectodysplasin, an essential effector in the formation of zig-zag hair. Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development.

Publication metadata

Author(s): Narytnyk A, Gillinder K, Verdon B, Clewes O, Sieber-Blum M

Publication type: Article

Publication status: Published

Journal: Stem Cell Reviews and Reports

Year: 2014

Volume: 10

Issue: 1

Pages: 60-68

Print publication date: 18/08/2013

Date deposited: 21/05/2014

ISSN (print): 1550-8943

ISSN (electronic): 1558-6804

Publisher: Humana Press


DOI: 10.1007/s12015-013-9466-z


Altmetrics provided by Altmetric


Funder referenceFunder name
Newcastle University
22358Medical Research Council