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Lookup NU author(s): Dr Zohreh Nademi, Professor Sophie Hambleton, Dr Terence Flood, Professor Andrew Cant, Dr Mario Abinun, Professor Mary Slatter, Professor Andrew GenneryORCiD
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Cord blood transplantation (CBT) is curative for many primary immunodeficiencies (PIDs) but is associated with risks of viral infection and graft-versus-host disease (GvHD). Serotherapy reduces GvHD but potentially increases the risk of viral infection by delaying immune reconstitution. Because many PID patients have preexisting viral infections, the optimal dose of serotherapy is unclear. We performed a retrospective analysis in 34 consecutive PID patients undergoing CBT and compared immune reconstitution, viral infection, GvHD, mortality, and long-term immune function between high-dose (n = 11) and low-dose (n = 9) serotherapy. Serotherapy dose had no effect on neutrophil engraftment. Median CD3(+) engraftment occurred at 92.5 and 97 days for high- and low-dose serotherapy, respectively. The low-dose serotherapy group had higher CD3(+), CD4(+), and early thymic emigrant counts at 4 months compared with the high-dose group. GvHD severity and number of viral infections did not differ between serotherapy doses. Survival from the transplantation process was 90.9% for high-dose and 100% for low-dose groups. In conclusion, low-dose serotherapy enhanced T cell reconstitution and thymopoiesis during the first year after CBT with no increase in GvHD. (C) 2014 American Society for Blood and Marrow Transplantation.
Author(s): Lane JR, Evans PTG, Nademi Z, Barge D, Jackson A, Hambleton S, Flood TJ, Cant AJ, Abinun M, Slatter MA, Gennery AR
Publication type: Article
Publication status: Published
Journal: Biology of Blood and Marrow Transplantation
Year: 2014
Volume: 20
Issue: 2
Pages: 243-249
Print publication date: 10/11/2013
ISSN (print): 1083-8791
ISSN (electronic): 1523-6536
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.bbmt.2013.11.005
DOI: 10.1016/j.bbmt.2013.11.005
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