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Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Lookup NU author(s): Professor Peter Thomson

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Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.


Publication metadata

Author(s): Leoncini E, Ricciardi W, Cadoni G, Arzani D, Petrelli L, Paludetti G, Brennan P, Luce D, Stucker I, Matsuo K, Talamini R, La Vecchia C, Olshan AF, Winn DM, Herrero R, Franceschi S, Castellsague X, Muscat J, Morgenstern H, Zhang ZF, Levi F, Dal Maso L, Kelsey K, McClean M, Vaughan T, Lazarus P, Purdue MP, Hayes RB, Chen C, Schwartz SM, Shangina O, Koifman S, Ahrens W, Matos E, Lagiou P, Lissowska J, Szeszenia-Dabrowska N, Fernandez L, Menezes A, Agudo A, Daudt AW, Richiardi L, Kjaerheim K, Mates D, Betka J, Yu GP, Schantz S, Simonato L, Brenner H, Conway DI, Macfarlane TV, Thomson P, Fabianova E, Znaor A, Rudnai P, Healy C, Boffetta P, Chuang SC, Lee YCA, Hashibe M, Boccia S

Publication type: Article

Publication status: Published

Journal: European Journal of Epidemiology

Year: 2014

Volume: 29

Issue: 1

Pages: 35-48

Print publication date: 01/01/2014

ISSN (print): 0393-2990

ISSN (electronic): 1573-7284

Publisher: Springer Netherlands

URL: http://dx.doi.org/10.1007/s10654-013-9863-2

DOI: 10.1007/s10654-013-9863-2


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Funding

Funder referenceFunder name
Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center
Fondation pour la Recherche Medicale (FRM)
Fondazione Veronesi
French Institute for Public Health Surveillance (InVS)
French National Research Agency (ANR)
Ministry of Health
Ministry of Labour
Ministry of Science, Research and Arts Baden-Wurttemberg
National Institutes of Health (NCI) US
Swiss League against Cancer
World Cancer Research Fund
Yamagiwa-Yoshida Memorial International Cancer Study Grant
Fondation de France
Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina
French Agency for Food, Environmental and Occupational Health and Safety (ANSES)
French Association for Research on Cancer (ARC)
French National Cancer Institute (INCA)
IMIM (Barcelona)
International Union Against Cancer (UICC)
Italian Association for Research on Cancer (AIRC)
Italian League Against Cancer
Italian Ministry of Research
NCI, NIH, United States
NIDCR
01/01768-2Fundaco de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP)
10068Italian Association for Research on Cancer (AIRC)
17015052Ministry of Education, Science, Sports, Culture and Technology of Japan
10491AIRC (Italian Agency for Research on Cancer)
BAE 01/5013Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government
FIS 97/0024Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government
FIS 97/0662Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government
IC15- CT98-0332European Commission INCO-COPERNICUS Program
IC18-CT97-0222European Commission
H20-002Ministry of Health, Labor and Welfare of Japan
K07CA104231National Institute of Health (NIH) US
KFS-700Swiss Research against Cancer/Oncosuisse
OCS-1633Swiss Research against Cancer/Oncosuisse
P01CA068384 K07CA104231National Institute of Health (NIH) US
QLK1-CT-2001-00182European Community
R01CA051845NIH
R01DA011386National Institute of Health (NIH) US
R21ES011667National Institute of Health (NIH) US
P01CA068384National Institute of Health (NIH) US
P30ES010126National Institute of Environmental Health Sciences
P50CA090388National Institute of Health (NIH) US
PRIN 2009 X8YCBNItalian Ministry of Education
R01CA030022NIH
R01CA048996National Institute of Health (NIH) US
R01CA061188National Institute of Health (NIH) US
R01CA078609National Institutes of Health (NIH) US
R01CA100679National Institutes of Health (NIH) US
R01DE012609National Institute of Health (NIH) US
R01DE013158National Institute of Health (NIH) US
R03CA077954National Institute of Health (NIH) US
T32CA009142National Institute of Health (NIH) US
U01CA096134National Institute of Health (NIH) US

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