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fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies

Lookup NU author(s): Dr Luis Peraza Rodriguez, Professor Marcus Kaiser, Dr Michael Firbank, Dr Sara Graziadio, Dr Sean Colloby, Professor Andrew Blamire, Professor John-Paul Taylor



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Cognitive fluctuations are a core symptom in dementia with Lewy bodies (DLB) and may relate to pathological alterations in distributed brain networks. To test this we analysed resting state fMRI changes in a cohort of fluctuating DLB patients (n=16) compared with age matched controls (n=17) with the aim of finding functional connectivity (FC) differences between these two groups and whether these associate with cognitive fluctuations in DLB. Resting state networks (RSNs) were estimated using independent component analysis and FC between the RSN maps and the entirety of the brain was assessed using dual regression. The default mode network (DMN) appeared unaffected in DLB compared to controls but significant cluster differences between DLB and controls were found for the left fronto-parietal, temporal, and sensory-motor networks. Desynchronisation of a number of cortical and subcortical areas related to the left fronto-parietal network was associated with the severity and frequency of cognitive fluctuations. Our findings provide empirical evidence for the potential role of attention-executive networks in the aetiology of this core symptom in DLB.

Publication metadata

Author(s): Peraza LR, Kaiser M, Firbank M, Graziadio S, Bonanni L, Onofrj M, Colloby SJ, Blamire A, O'Brien J, Taylor J-P

Publication type: Article

Publication status: Published

Journal: Neuroimage: Clinical

Year: 2014

Volume: 4

Pages: 558-565

Online publication date: 28/03/2014

Acceptance date: 27/03/2014

Date deposited: 03/09/2014

ISSN (electronic): 2213-1582

Publisher: Elsevier BV


DOI: 10.1016/j.nicl.2014.03.013


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