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Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease

Lookup NU author(s): Dr Emma Vardy, Dr Sarah Cocklin


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Background: Tissue non-specific alkaline phosphatase (TNAP) has been shown to promote the neurotoxicity of extracellular tau which contributes to the spread of pathology in Alzheimer’s disease (AD). Objective: To investigate changes in TNAP activity in the hippocampus in both sporadic and familial AD, and to examine whether changes in neuronal TNAP are reflected systemically by looking at changes in plasma TNAP activity in AD. Methods: We measured the activity of TNAP in the hippocampus in sporadic AD, familial AD and appropriate age-matched controls, and in an ageing series (age: 25–88 years) of brains. In addition, we measured TNAP activity in plasma from 110 AD and 110 non-demented control participants. Results: TNAP activity was significantly increased in the hippocampus in sporadic (by 56%; p = 0.038) and familial AD (by 121%; p = 0.042) compared with the age-matched controls. However, there was no correlation of TNAP activity with age. Furthermore, plasma TNAP activity was increased in AD (by 13%; p = 0.018) and inversely correlated with cognitive function (rs = –0.211; p = 0.027). Conclusion: Together, these data indicate that TNAP is increased in both sporadic and familial AD but not in the aged brain, indicating that the increase is likely a consequence of AD-associated changes in the brain. The neuronal change in TNAP is reflected in an increase in plasma TNAP in AD and is inversely correlated with cognitive function.

Publication metadata

Author(s): Vardy ER, Kellett KA, Cocklin SL, Hooper NM

Publication type: Article

Publication status: Published

Journal: Neurodegenerative Diseases

Year: 2012

Volume: 9

Issue: 1

Pages: 31-37

Print publication date: 01/11/2011

ISSN (print): 1660-2854

ISSN (electronic): 1660-2862

Publisher: S. Karger AG


DOI: 10.1159/000329722

PubMed id: 22024719


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