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NF-kB and the cell cycle

Lookup NU author(s): Dr Adeline Ledoux, Professor Neil PerkinsORCiD


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The NF-kappa B (nuclear factor kappa B) transcription factor family is a pleiotropic regulator of many cellular pathways, providing a mechanism for the cell to respond to a wide variety of stimuli and environmental challenges. It is not surprising therefore that an important component of NF-kappa B's function includes regulation of the cell cycle. However, this aspect of its behaviour is often overlooked and receives less attention than its ability to induce inflammatory gene expression. In the present article, we provide an updated review of the current state of our knowledge about integration of NF-kappa B activity with cell cycle regulation, including newly characterized direct and indirect target genes in addition to the mechanisms through which NF-kappa B itself can be regulated by the cell cycle.

Publication metadata

Author(s): Ledoux AC, Perkins ND

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2014

Volume: 42

Issue: 1

Pages: 76-81

Print publication date: 01/02/2014

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.


DOI: 10.1042/BST20130156


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Funder referenceFunder name
European Union Framework Programme 7 'Inflacare' consortium
C1443/A9215Cancer Research UK
C1443/A12750Cancer Research UK