Toggle Main Menu Toggle Search

Open Access padlockePrints

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury

Lookup NU author(s): Dr Aaron Liew

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery.


Publication metadata

Author(s): Riegler J, Liew A, Hynes SO, Ortega D, O'Brien T, Day RM, Richards T, Sharif F, Pankhurst QA, Lythgoe MF

Publication type: Article

Publication status: Published

Journal: Biomaterials

Year: 2013

Volume: 34

Issue: 8

Pages: 1987-1994

Print publication date: 11/12/2012

ISSN (print): 0142-9612

ISSN (electronic): 1878-5905

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.biomaterials.2012.11.040

DOI: 10.1016/j.biomaterials.2012.11.040

PubMed id: 23237516


Altmetrics

Altmetrics provided by Altmetric


Share