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Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury

Lookup NU author(s): Dr Aaron Liew

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Abstract

Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery.

Publication metadata

Author(s): Riegler J, Liew A, Hynes SO, Ortega D, O'Brien T, Day RM, Richards T, Sharif F, Pankhurst QA, Lythgoe MF

Publication type: Article

Publication status: Published

Journal: Biomaterials

Year: 2013

Volume: 34

Issue: 8

Pages: 1987-1994

Print publication date: 11/12/2012

ISSN (print): 0142-9612

ISSN (electronic): 1878-5905

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.biomaterials.2012.11.040

DOI: 10.1016/j.biomaterials.2012.11.040

PubMed id: 23237516

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