Browse by author
Lookup NU author(s): Dr Achim Treumann
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Human cancers utilise telomerase to maintain telomeres and prohibit cell senescence. Human telomerase reverse transcriptase (hTERT), an essential component of this complex, is regulated at the level of gene transcription. Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2. In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P<0.01, P=0.05 and P=0.03 respectively, n=170). These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences.
Author(s): Flavin P, Redmond A, McBryan J, Cocchiglia S, Tibbitts P, Fahy-Browne P, Kay E, Treumann A, Perrem K, McIlroy M, Hill AD, Young LS
Publication type: Article
Publication status: Published
Journal: FEBS Letters
Print publication date: 04/08/2011
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
Publisher: Elsevier BV
PubMed id: 21763315
Altmetrics provided by Altmetric