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Lookup NU author(s): Dr Fernando Santos Beneit
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The biosynthesis of many antibiotics is regulated negatively by highinorganic phosphate concentrations in the medium. Streptomyces speciesproduce a wide variety of bioactive compounds, including more than thehalf of all commercial antibiotics. The Pho regulon plays a key role inbacterial phosphate homeostasis. This system has been well characterizedin several bacteria, inclusive of Streptomyces and S. coelicolor, the modelorganism of the Streptomyces genus. This chapter provides a detailedoverview of phosphate regulation in bacteria, focusing in streptomycetes,in which the Pho regulon has been shown to be involved not only inphosphate metabolism but also in different pathways like nitrogenassimilation or antibiotic production. Knowledge in phosphate regulationpromises to be very important for the development of new biotechnologicalimprovements.
Author(s): Santos-Beneit F
Editor(s): Tewari, R
Series Editor(s): Govil, J.N.
Publication type: Book Chapter
Publication status: Published
Book Title: Microbial Biotechnology
Year: 2014
Volume: 3
Pages: 135-153
Series Title: Biotechnology
Number of Volumes: 12
Publisher: Studium Press LLC
Place Published: New Delhi
Library holdings: Search Newcastle University Library for this item
ISBN: 9781626990180
