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Reversible Non-Stick Behaviour of a Bacterial Protein Polymer Provides a Tuneable Molecular Mimic for Cell and Tissue Engineering

Lookup NU author(s): Ana Roque, Dr Andrei Soliakov, Dr Mark Birch, Emeritus Professor Jeremy LakeyORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Yersina pestis, the bubonic plague bacterium, is coated with a polymeric protein hydrogel for protection from host defences. The protein, which is robust and non-stick, resembles structures found in many eukaryotic extracellular-matrix proteins. Cells grown on the natural polymer cannot adhere and grow poorly; however, when cell-adhesion motifs are inserted into the protein, the cells proliferate

Publication metadata

Author(s): Roque AI, Soliakov A, Birch MA, Philips SR, Shah DS, Lakey JH

Publication type: Article

Publication status: Published

Journal: Advanced Materials

Year: 2014

Volume: 26

Issue: 17

Pages: 2704-2709

Print publication date: 13/03/2014

Date deposited: 23/06/2014

ISSN (print): 0935-9648

ISSN (electronic): 1521-4095

Publisher: Wiley - VCH Verlag GmbH & Co. KGaA

URL: http://dx.doi.org/10.1002/adma.201304645

DOI: 10.1002/adma.201304645

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