Toggle Main Menu Toggle Search

Open Access padlockePrints

Quality of Life and Mild Cognitive Impairment in Early Parkinson's Disease: Does Subtype Matter?

Lookup NU author(s): Dr Rachael LawsonORCiD, Professor Alison Yarnall, Dr Gordon Duncan, Dr Tien Kheng Khoo, Professor John-Paul TaylorORCiD, Professor David Burn



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia. Participants completed neuropsychological tests of attention, executive function, visuospatial function, memory, and language, and reported QoL using the Parkinson's Disease Questionnaire. Impairments were most common in executive function, memory and attention. MCI subtypes were classified according to Movement Disorder Society Task Force criteria. More severe cognitive impairment was associated with poorer quality of life (p = 0.01), but subtype of impairment was not (p > 0.10), suggesting that the nature of cognitive impairment is less significant than its severity.

Publication metadata

Author(s): Lawson RA, Yarnall AJ, Duncan GW, Khoo TK, Breen DP, Barker RA, Collerton D, Taylor JP, Burn DJ

Publication type: Article

Publication status: Published

Journal: Journal of Parkinson's Disease

Year: 2014

Volume: 4

Issue: 3

Pages: 331-336

Print publication date: 02/09/2014

Online publication date: 11/06/2014

Date deposited: 14/08/2015

ISSN (print): 1877-7171

ISSN (electronic): 1877-718X

Publisher: IOS Press


DOI: 10.3233/JPD-140390

PubMed id: 24919824


Altmetrics provided by Altmetric


Funder referenceFunder name
Parkinson's UK
UK NIHR Biomedical Research Centre
UK NIHR Biomedical Research Centre for Ageing and Age-Related Disease
UK NIHR Biomedical Research Unit in Lewy Body Dementia
Raymond and Beverly Sackler Studentship
Wellcome Trust Intermediate Clinical Fellowship
088441/Z/09/ZWellcome Trust