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Patterns of cerebellar volume loss in dementia with Lewy bodies and Alzheimer's disease: A VBM-DARTEL study

Lookup NU author(s): Dr Sean Colloby, Professor John O'Brien, Professor John-Paul TaylorORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Evidence suggests that the cerebellum contributes to cognition as well as motor function. We investigated cerebellar grey matter (GM) and white matter (WM) changes from magnetic resonance images in dementia with Lewy bodies (DLB), Alzheimer׳s disease (AD) and healthy older subjects using voxel-based morphometry (VBM). Subjects (39 controls, 41 DLB, and 48 AD) underwent magnetic resonance imaging as well as clinical and cognitive assessments. VBM used SPM8 with a cerebellar brain mask to define the subspace for voxel analysis. Statistical analyses were conducted using the general linear model. Relative to findings in controls, VBM analysis revealed cerebellar GM loss in lobule VI bilaterally in AD and in left Crus I and right Crus II regions in DLB. WM deficits were confined to AD in the bilateral middle cerebellar peduncles. DLB demonstrates a different pattern of cerebellar GM loss which, although not significantly different from that in AD, could be an important feature in understanding the neurobiology of DLB and warrants further investigation.

Publication metadata

Author(s): Colloby SJ, O'Brien JT, Taylor J-P

Publication type: Article

Publication status: Published

Journal: Psychiatric Research: Neuroimaging

Year: 2014

Volume: 223

Issue: 3

Pages: 187-191

Print publication date: 30/09/2014

Online publication date: 30/06/2014

Acceptance date: 19/06/2014

Date deposited: 29/08/2014

ISSN (print): 0925-4927

ISSN (electronic): 1872-7506

Publisher: Elsevier


DOI: 10.1016/j.pscychresns.2014.06.006


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Funder referenceFunder name
Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle University
NIHR Dementia Biomedical Research Unit at Cambridge University Hospitals NHS Foundation Trust
National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre in Ageing and Chronic Disease
University of Cambridge
BH0070250Newcastle Healthcare Charity
BH083281Wellcome Intermediate Clinical Fellowship
BH090112Academy of Medical Sciences, Wellcome Trust
088441/Z/09/ZWellcome Trust