ePrints

Nocardichelins A and B, siderophores from Nocardia strain Acta 3026

Lookup NU author(s): Professor Michael Goodfellow

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

Publication metadata

Author(s): Schneider K, Rose I, Sussmuth RD, Vikeneswary V, Jones AL, Goodfellow M, Nicholson G, Bell W, Fiedler H-P

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2007

Volume: 70

Issue: 6

Pages: 932-935

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/np060612i

DOI: 10.1021/np060612i

Altmetrics

Share