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Pneumococcal diagnosis and serotypes in childhood community-acquired pneumonia

Lookup NU author(s): Dr Mohamed Elemraid, Dr Matthew Thomas, Professor Stephen Rushton, Dr John Perry, Dr David Spencer, Dr Katherine Eastham, Dr Fiona Hampton, Professor Andrew GenneryORCiD



The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced routinely in the UK from September 2006 and replaced by PCV13 in 2010. In a prospective study from 2009 to 2011 of 160 children aged <= 16 years with radiologically confirmed pneumonia, likely pneumococcal infections were identified in 26%. Detection of pneumococci was improved with polymerase chain reaction compared to culture (21.6% versus 6% of children tested, P = 0.0004). Where serotyping was possible, all (n = 23) were non-PCV7 but PCV13 serotypes; 1 (43.5%), 3 (21.7%), 7A/F, and 19A (17.4% each). (C) 2013 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Elemraid MA, Sails AD, Thomas MF, Rushton SP, Perry JD, Eltringham GJA, Spencer DA, Eastham KM, Hampton F, Gennery AR, Clark JE, North East of England Paediatric Respiratory Infection Study Group

Publication type: Article

Publication status: Published

Journal: Diagnostic Microbiology and Infectious Disease

Year: 2013

Volume: 76

Issue: 2

Pages: 129-132

Print publication date: 01/06/2013

Online publication date: 26/03/2013

Acceptance date: 19/02/2013

Date deposited: 05/01/2015

ISSN (print): 0732-8893

ISSN (electronic): 1879-0070

Publisher: Elsevier


DOI: 10.1016/j.diagmicrobio.2013.02.012


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Funder referenceFunder name
0887X1-4479Pfizer Vaccines UK