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Epidemiological survey of Clostridium difficile ribotypes in the North East of England during an 18-month period

Lookup NU author(s): Kirsten Hill, Dr Andrew Berrington, Dr John Perry, Professor John Magee, Professor Kate Gould


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During an 18-month period, 1606 stool specimens from laboratory-confirmed cases of Clostridium difficile infection in the North East of England were ribotyped using unrestricted polymerase chain reaction. Of these, 87.6% grew C. difficile on culture; 70% had one of 10 recognizable ribotypes of which 001, 106 and 027 were the most prevalent. The proportions of ribotypes 002 and 015 declined during the study period, whereas ribotypes 016 and 023 increased. Ribotype 005 was significantly more numerous in males and ribotype 027 was associated with significantly higher mean age. Our findings differ from national data derived from more selective testing. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Vanek J, Hill K, Collins J, Berrington A, Perry J, Inns T, Gorton R, Magee J, Sails A, Mullan A, Gould FK

Publication type: Article

Publication status: Published

Journal: Journal of Hospital Infection

Year: 2012

Volume: 81

Issue: 3

Pages: 209-212

Print publication date: 24/05/2012

ISSN (print): 0195-6701

ISSN (electronic): 1532-2939

Publisher: WB Saunders Co. Ltd


DOI: 10.1016/j.jhin.2012.04.017


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