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Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Lookup NU author(s): Dr Fiona Douglas



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify individuals with clinically relevant prostate cancer. Male BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. Urine samples from 413 BRCA1 and BRCA2 mutation carriers and controls were evaluated. Subjects underwent annual PSA screening with diagnostic biopsy triggered by PSA >3.0 ng/ml; 21 men were diagnosed with prostate cancer. Urinary EN2 levels were measured by ELISA and had a sensitivity of 66.7% and specificity of 89.3% for cancer detection. There was no statistically significant difference in EN2 levels according to genetic status or Gleason score. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals.

Publication metadata

Author(s): Killick E, Morgan R, Launchbury F, Bancroft E, Page E, Castro E, Kote-Jarai Z, Aprikian A, Blanco I, Clowes V, Domchek S, Douglas F, Eccles D, Evans DG, Harris M, Kirk J, Lam J, Lindeman G, Mitchell G, Pachter N, Selkirk C, Tucker K, Zgajnar J, Eeles R, Pandha H

Publication type: Article

Publication status: Published

Journal: Scientific Reports

Year: 2013

Volume: 3

Online publication date: 24/06/2013

Acceptance date: 03/06/2013

Date deposited: 13/11/2015

ISSN (electronic): 2045-2322

Publisher: Nature Publishing Group


DOI: 10.1038/srep02059

PubMed id: 23792811


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Funder referenceFunder name
Annabel Evans Memorial Fund
Basser Research Centre
Prostate Project Charity
Ronald & Rita McAulay Foundation
1006349Cancer Australia
400048Cancer Council of Victoria
400048Cancer Council of South Australia
C5047/A13232Cancer Research UK
C5047/A8385Cancer Research UK
PCFA PRO4Prostate Cancer Foundation of Australia