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Anal sphincter fibrillation: is this a new finding that identifies resistant chronic anal fissures that respond to botulinum toxin?

Lookup NU author(s): Praminthra Chitsabesan, Dr Stefan Plusa


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Aim Anal fissures can be resistant to treatment and some patients may undergo several trials of medical therapy before definitive surgery. It would be useful to identify predictors of poor response to medical therapy. This study assesses the role of anorectal physiological criteria to identify patients with anal fissure predicted to fail botulinum toxin (BT) treatment.Method A retrospective analysis of anorectal physiological data collected for patients with resistant chronic anal fissures, referred to one consultant surgeon between 2007 and 2011, was undertaken. These were correlated with treatment plans and healing rates.Results Twenty-five patients with idiopathic chronic anal fissures underwent anorectal physiology studies and were subsequently treated with BT injection. Eleven had a characteristic high-frequency low-amplitude 'saw tooth' waveform or anal sphincter fibrillation (ASF) and higher anal sphincter pressures. Nine (82%) of these patients had resolution of their anal fissure symptoms following treatment with BT. Of 14 patients with no evidence of ASF and a greater range of anal sphincter pressures, only one (7%) had resolution following BT.Conclusion ASF appears to be an anorectal physiological criterion that helps predict response of anal fissures to BT injection. This could help streamline fissure management.

Publication metadata

Author(s): Moon A, Chitsabesan P, Plusa S

Publication type: Article

Publication status: Published

Journal: Colorectal Disease

Year: 2013

Volume: 15

Issue: 8

Pages: 1007-1010

Print publication date: 01/08/2013

Online publication date: 29/08/2013

Acceptance date: 13/10/2012

ISSN (print): 1462-8910

ISSN (electronic): 1463-1318

Publisher: Wiley-Blackwell


DOI: 10.1111/codi.12212


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