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Role of interleukin-13 in fibrosis, particularly systemic sclerosis

Lookup NU author(s): Dr Steven O'Reilly


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Chronic inflammation can lead to altered extracellular matrix deposition and ultimately fibrosis. Interleukin-13 (IL-13) is a cytokine that was found to promote IgE class switching and inhibit proinflammatory cytokines. However, it is now recognized as an important mediator in allergy and most importantly fibrosis. Indeed, animal studies with genetically deleted mice have demonstrated its critical role in fibrosis and although it shares over lapping functions with IL-4 it is the dominant cytokine in fibrosis. Systemic sclerosis is an autoimmune disease in which there is chronic inflammation and fibrosis. The disease is associated with a Th2 polarization and IL-13 levels are elevated both in the blood and in the skin of patients. This review will examine the role of IL-13 in driving fibrosis with a particular emphasis on systemic sclerosis as a prototypical fibrotic disease. It will highlight recent research into the role of IL-13 and how this cytokine may be targeted in systemic sclerosis. (c) 2013 BioFactors, 39(6):593-596, 2013

Publication metadata

Author(s): O'Reilly S

Publication type: Review

Publication status: Published

Journal: BioFactors

Year: 2013

Volume: 39

Issue: 6

Pages: 593-596

Print publication date: 01/11/2013

Online publication date: 25/07/2013

Acceptance date: 07/05/2013

ISSN (print): 0951-6433

ISSN (electronic): 1872-8081



DOI: 10.1002/biof.1117