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Contrast agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy

Lookup NU author(s): Professor Volker Straub

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Abstract

Membrane lesions play an early role in the pathogenesis of muscular dystrophy. Using a new albumin-targeted contrast agent (MS-325), sarcolemmal integrity of two animal models for muscular dystrophy was studied by MRI. Intravenously injected MS-325 does not enter skeletal muscle of normal mice. However, mdx and Sgca-null mutant mice, animal models for Duchenne and sarcoglycan-deficient limb-girdle muscular dystrophy, respectively, showed significant accumulation of MS-325 in skeletal muscle. The results suggest that contrast agent-enhanced MRI could serve as a common, noninvasive imaging procedure for evaluating the localization, extent, and mechanisms of skeletal muscle damage in muscular dystrophy. Furthermore, this method is expected to facilitate assessment of therapeutic approaches in these diseases.


Publication metadata

Author(s): Straub V, Donahue KM, Allamand V, Davisson RL, Kim YR, Campbell KP

Publication type: Article

Publication status: Published

Journal: Magnetic Resonance in Medicine

Year: 2000

Volume: 44

Issue: 4

Pages: 655-659

ISSN (print): 0740-3194

ISSN (electronic): 1522-2594

Publisher: John Wiley & Sons

URL: http://www.physiology.uiowa.edu/CAMPBELL/Publications/PDF/277StraubMagResonanceMed.pdf

PubMed id: 11025524


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