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Hereditary mtDNA Heteroplasmy: A Baseline for Aging?

Lookup NU author(s): Dr Michael Keogh, Professor Patrick Chinnery


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Do mtDNA mutations contribute to the aging process, or are they innocent bystanders? Ross et al. (2013) show that inherited mtDNA point mutations lead to a premature aging phenotype in mice and "prime'' the maternal lineage, interacting with subsequent somatic mutations to cause brain malformations and shorten lifespan.

Publication metadata

Author(s): Keogh M, Chinnery PF

Publication type: Editorial

Publication status: Published

Journal: Cell Metabolism

Year: 2013

Volume: 18

Issue: 4

Pages: 463-464

Print publication date: 01/10/2013

Online publication date: 01/10/2013

ISSN (print): 1550-4131

ISSN (electronic): 1932-7420

Publisher: Cell Press


DOI: 10.1016/j.cmet.2013.09.015