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Pharmacokinetic interaction between voriconazole and ciclosporin A following allogeneic bone marrow transplantation

Lookup NU author(s): Professor Hermann Josef Vormoor

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Abstract

Voriconazole is a novel antifungal triazole that undergoes extensive oxidative metabolization involving several CYP450 isoenzymes. We report the case of a 14-year-old patient who received voriconazole concomitant with ciclosporin A as secondary antifungal prophylaxis after bone marrow transplantation. Temporary discontinuation of voriconazole due to worsening liver function tests (LFTs) resulted in a sudden drop of ciclosporin A trough levels in blood. Ciclosporin A trough levels returned to baseline following normalization of LFTs and re-institution of voriconazole. This report emphasizes the need for careful monitoring and dose adjustments of ciclosporin A in patients receiving concomitant voriconazole, and in whom voriconazole is discontinued in order to prevent subtherapeutic ciclosporin A levels with the potential consequence of graft-versus-host disease.

Publication metadata

Author(s): Groll AH, Kolve H, Ehlert K, Paulussen M, Vormoor J

Publication type: Article

Publication status: Published

Journal: Journal of Antimicrobial Chemotherapy

Year: 2004

Volume: 53

Issue: 1

Pages: 113-114

ISSN (print): 0305-7453

ISSN (electronic): 1460-2091

URL: http://dx.doi.org/10.1093/jac/dkh022

DOI: 10.1093/jac/dkh022

Notes: 0305-7453 (Print) Case Reports Journal Article

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