Browse by author
Lookup NU author(s): Dr Sujith Samarasinghe
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Aplastic anaemia (AA) is a rare heterogeneous condition in children. 1520% of cases are constitutional and correct diagnosis of these inherited causes of AA is important for appropriate management. For idiopathic severe aplastic anaemia, a matched sibling donor (MSD) haematopoietic stem cell transplant (HSCT) is the treatment of choice. If a MSD is not available, the options include immunosuppressive therapy (IST) or unrelated donor HSCT. IST with horse anti-thymocyte globulin (ATG) is superior to rabbit ATG and has good long-term results. In contrast, IST with rabbit ATG has an overall response of only 3040%. Due to improvements in outcome over the last two decades in matched unrelated donor (MUD) HSCT, results are now similar to that of MSD HSCT. The decision to proceed with IST with ATG or MUD HSCT will depend on the likelihood of finding a MUD and the differing risks and benefits that each therapy provides.
Author(s): Samarasinghe S, Webb DKH
Publication type: Review
Publication status: Published
Journal: British Journal of Haematology
Print publication date: 20/02/2012
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141