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Elastic properties of peripheral arteries in heart failure patients in comparison with normal subjects

Lookup NU author(s): Dr Ding Chang Zheng, Emeritus Professor Alan MurrayORCiD


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Understanding the change in elastic properties of peripheral arteries in heart failure patients is of particular importance, especially when compared with normal subjects. To investigate factors associated with their difference, 40 normal subjects and 60 heart failure patients were studied. Electrocardiograms, carotid pulses and radial pulses were simultaneously recorded to determine carotid-radial pulse transit time (carotid-radial PTT), arm pulse wave velocity (PWV), and arterial volume distensibility. In comparison with normal subjects, carotid-radial PTT was lower by 8 ms in heart failure patients, arm PWV higher by 1.4 m/s, and peripheral arterial distensibility lower by 0.04 % per mmHg (all significant, P < 0.01). Peripheral arterial distensibility was significantly related to systolic blood pressure (SBP) and to left ventricular ejection fraction (LVEF) for heart failure patients (both P < 0.001), but the relationship for the normal group was not statistically significant (both 0.05 < P < 0.1). Ageing had a significant inverse relationship with arterial distensibility in normal subjects (P < 0.05), but not in heart failure patients (P = 0.59). No subject in the normal group had an arterial distensibility lower than 0.1 % per mmHg, in comparison with 28 % (17/60) in the heart failure group. Peripheral arterial distensibility has been shown to be significantly lower in heart failure patients in comparison with normal subjects. High SBP and low LVEF were the main factors associated with low arterial distensibility in heart failure patients.

Publication metadata

Author(s): Liu CY, Zheng DC, Zhao LN, Li P, Li B, Murray A, Liu CC

Publication type: Article

Publication status: Published

Journal: Journal of Physiological Sciences

Year: 2013

Volume: 63

Issue: 3

Pages: 195-201

Print publication date: 01/05/2013

Online publication date: 22/03/2013

Acceptance date: 08/03/2013

ISSN (print): 1880-6546

ISSN (electronic): 1880-6562

Publisher: Springer Japan


DOI: 10.1007/s12576-013-0254-y


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Funder referenceFunder name
2009AA02Z408Hi-Tech Research and Development Program of China
20110491593China Postdoctoral Science Foundation
61201049National Natural Science Foundation of China