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Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial

Lookup NU author(s): Helen Spencer, Professor Douglas Turkington


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Aims: Recent evidence regarding over-estimation of the efficacy of antipsychotics and under-estimation of their toxicity, as well as emerging data regarding alternative treatment options, suggest it may be time to introduce patient choice. However, only a small number of studies have reported on the efficacy of interventions for psychological interventions such as cognitive therapy. Early results suggest that cognitive therapy may be an effective, well-tolerated treatment for people who choose not to take antipsychotics. We report on the rationale and design for a multi-site randomised, controlled trial of cognitive therapy for people with a schizophrenia spectrum diagnosis who choose not to take antipsychotics.Methods: The study employs a single-blind design in which all participants receive treatment as usual, and half are randomised to up to 30 sessions of cognitive therapy for up to 9 months. Participants will be followed-up for a minimum of 9 months and to a maximum of 18 months.Results: We report the characteristics of the final sample at baseline (N = 74).Conclusions: Our study aims to expand the currently limited evidence base for best practice in interventions for individuals with psychosis who choose not to take antipsychotics.

Publication metadata

Author(s): Morrison AP, Wardle M, Hutton P, Davies L, Dunn G, Brabban A, Byrne R, Drage L, Spencer H, Turkington D

Publication type: Article

Publication status: Published

Journal: Psychosis: Psychological, Social and Integrative Approaches

Year: 2013

Volume: 5

Issue: 1

Pages: 82-92

Online publication date: 06/02/2013

Acceptance date: 04/12/2012

ISSN (print): 1752-2439

ISSN (electronic): 1752-2447

Publisher: Routledge


DOI: 10.1080/17522439.2012.756539


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