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Low molecular weight Neutral Boron Dipyrromethene (Bodipy) dyads for fluorescence-based neural imaging

Lookup NU author(s): Dan Bai, Professor Andrew Benniston, Sophie Clift, Dr Ulrich Baisch, Dr Jannetta Steyn, Nicola Everitt, Dr Peter Andras


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The neutral low molecular weight julolidine-based borondipyrromethene (Bodipy) dyads JULBD and MJULBD were used for fast voltage-sensitive dye imaging of neurons in the crab stomatogastric ganglion. The fluorescence modulation of the dyads mirrors alterations in the membrane potential of the imaged neurons. The toxicity of the dyes towards the neurons is related to their structure in that methyl groups at the 3,5 positions results in reduced toxic effects. (C) 2014 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Bai D, Benniston AC, Clift S, Baisch U, Steyn J, Everitt N, Andras P

Publication type: Article

Publication status: Published

Journal: Journal of Molecular Structure

Year: 2014

Volume: 1065-1066

Pages: 10-15

Print publication date: 22/02/2014

ISSN (print): 0022-2860

ISSN (electronic): 1872-8014

Publisher: Elsevier Science


DOI: 10.1016/j.molstruc.2014.02.026


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Funder referenceFunder name
Newcastle University
EP/G0409X/1Engineering and Physical Sciences Research Council (EPSRC)