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Lookup NU author(s): Eva Kenny, Professor John O'Brien, Dr Michael FirbankORCiD, Professor Andrew BlamireORCiD
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BackgroundResting-state functional magnetic resonance imaging (fMRI) can be used to measure correlations in spontaneous low-frequency fluctuations in the blood oxygen level-dependent (BOLD) signal which represent functional connectivity between key brain areas.AimsTo investigate functional connectivity with regions hypothesised to be differentially affected in dementia with Lewy bodies (DLB) compared with Alzheimer's disease and controls.MethodFifteen participants with probable DLB, 16 with probable Alzheimer's disease and 16 controls were scanned in the resting-state using a 3T scanner. The BOLD signal time-series of fluctuations in seed regions were correlated with all other voxels to measure functional connectivity.ResultsParticipants with DLB and Alzheimer's disease showed greater caudate and thalamic connectivity compared with. controls. Those with DLB showed greater putamen connectivity compared with those with Alzheimer's disease and the controls. No regions showed less connectivity in DLB or Alzheimer's disease v. controls, or in DLB v. Alzheimer's disease.ConclusionsAltered connectivity in DLB and Alzheimer's disease provides new insights into the neurobiology of these disorders and may aid in earlier diagnosis.
Author(s): Kenny ER, O'Brien JT, Firbank MJ, Blamire AM
Publication type: Article
Publication status: Published
Journal: British Journal of Psychiatry
Year: 2013
Volume: 203
Issue: 3
Pages: 209-214
Print publication date: 01/09/2013
Online publication date: 11/07/2013
Acceptance date: 03/04/2013
ISSN (print): 0007-1250
ISSN (electronic): 1472-1465
Publisher: Royal College of Psychiatrists
URL: http://dx.doi.org/10.1192/bjp.bp.112.108464
DOI: 10.1192/bjp.bp.112.108464
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