Toggle Main Menu Toggle Search

Open Access padlockePrints

Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy

Lookup NU author(s): Professor Andrew BlamireORCiD, Ian Wilson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 angstrom from a lanthanide ion. At this distance, the resonance is shifted to a region of the H-1 NMR spectral window far away from the usual 0-12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100-200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg(-1).

Publication metadata

Author(s): Harvey P, Blamire AM, Wilson JI, Finney KLNA, Funk AM, Senanayake PK, Parker D

Publication type: Article

Publication status: Published

Journal: Chemical Science

Year: 2013

Volume: 4

Issue: 11

Pages: 4251-4258

Print publication date: 01/11/2013

Online publication date: 19/08/2013

Acceptance date: 19/08/2013

ISSN (print): 2041-6520

ISSN (electronic): 2041-6539

Publisher: RSC Publications


DOI: 10.1039/c3sc51526e


Altmetrics provided by Altmetric


Funder referenceFunder name
FCC 266804ERC