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Lookup NU author(s): Professor Andrew Blamire,
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Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 angstrom from a lanthanide ion. At this distance, the resonance is shifted to a region of the H-1 NMR spectral window far away from the usual 0-12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100-200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg(-1).
Author(s): Harvey P, Blamire AM, Wilson JI, Finney KLNA, Funk AM, Senanayake PK, Parker D
Publication type: Article
Publication status: Published
Journal: Chemical Science
Print publication date: 01/11/2013
Online publication date: 19/08/2013
Acceptance date: 19/08/2013
ISSN (print): 2041-6520
ISSN (electronic): 2041-6539
Publisher: RSC Publications
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