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Lookup NU author(s): Professor Graham Jackson
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Myelofibrosis (MF) is a heterogeneous disease for which long-term, effective medical therapeutic options are currently limited. The role of allogeneic haematopoietic stem cell transplant (AHSCT) in this population, many of whom are elderly, often provides a challenge with regard to the identification of suitable candidates, timing of transplantation in the disease course and choice of conditioning regimen. This review summarizes key findings from published data concerning AHSCT in MF and attempts to provide a state of the art approach to MF-AHSCT in 2012. In addition, we postulate on how the era of JAK inhibition might impact on transplantation for MF.
Author(s): McLornan DP, Mead AJ, Jackson G, Harrison CN
Publication type: Review
Publication status: Published
Journal: British Journal of Haematology
Print publication date: 29/03/2012
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141