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Allogeneic Stem Cell Transplantation for Myelofibrosis in 2012

Lookup NU author(s): Professor Graham Jackson

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Abstract

Myelofibrosis (MF) is a heterogeneous disease for which long-term, effective medical therapeutic options are currently limited. The role of allogeneic haematopoietic stem cell transplant (AHSCT) in this population, many of whom are elderly, often provides a challenge with regard to the identification of suitable candidates, timing of transplantation in the disease course and choice of conditioning regimen. This review summarizes key findings from published data concerning AHSCT in MF and attempts to provide a state of the art approach to MF-AHSCT in 2012. In addition, we postulate on how the era of JAK inhibition might impact on transplantation for MF.

Publication metadata

Author(s): McLornan DP, Mead AJ, Jackson G, Harrison CN

Publication type: Review

Publication status: Published

Journal: British Journal of Haematology

Year: 2012

Volume: 157

Issue: 4

Pages: 413-425

Print publication date: 29/03/2012

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: WILEY-BLACKWELL

URL: http://dx.doi.org/10.1111/j.1365-2141.2012.09107.x

DOI: 10.1111/j.1365-2141.2012.09107.x

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