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Comparison of single lung transplant with and without the use of cardiopulmonary bypass

Lookup NU author(s): Dr Clare Burdett, Dr James Lordan, Professor John Dark, Stephen Clark


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OBJECTIVES: Many centres avoid using cardiopulmonary bypass (CPB) for lung transplant due to concerns over aggravated lung fusion injury and excessive blood loss. We reviewed our 23-years' experience of single lung transplantation.METHODS: A retrospective review of single lung transplants at our institution (1987-2010), examining differences in allograft and postoperative complications between CPB and non-bypass (non-CPB) cases.RESULTS: Two hundred and fifty-nine single lung transplants were undertaken. Fifty-three (20.5%) with CPB. There was no demographically between the two groups. No difference existed in preoperative PO2/FiO(2). At 1 and 24 h, the postoperative ratio was no different (mean 2.95 and 3.24 in non-CPB cases; 3.53 and 3.75 in CPB patients, P=0.18 and P=0.34, respectively). Extubation time was not influenced by the use of CPB. Postoperative blood loss was greater in the CPB group. The usage of frozen plasma and platelets was similar (P = 0.64 and 0.41, respectively). More blood was transfused during postoperative care of patients (P = 0.02).CONCLUSIONS: Fears of poor postoperative lung function after CPB appear unfounded. We could detect no difference in function extubation time. Although the use of CPB increases postoperative bleeding and the need for transfusion, it may be used safely to facilitate lung transplantation.

Publication metadata

Author(s): Burdett C, Butt T, Lordan J, Dark JH, Clark SC

Publication type: Article

Publication status: Published

Journal: Interactive Cardiovascular and Thoracic Surgery

Year: 2012

Volume: 15

Issue: 3

Pages: 432-436

Print publication date: 19/06/2012

ISSN (print): 1569-9293

ISSN (electronic): 1569-9285

Publisher: Oxford University Press


DOI: 10.1093/icvts/ivs264


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