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Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy?

Lookup NU author(s): Professor Robert Lightowlers, Professor Zofia Chrzanowska-LightowlersORCiD


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Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan etal () use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.

Publication metadata

Author(s): Lightowlers RN, Chrzanowska-Lightowlers ZMA

Publication type: Article

Publication status: Published

Journal: EMBO Molecular Medicine

Year: 2014

Volume: 6

Issue: 6

Pages: 705-707

Print publication date: 16/05/2014

ISSN (print): 1757-4676

ISSN (electronic): 1757-4684

Publisher: Wiley-Blackwell Publishing


DOI: 10.15252/emmm.201404179


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Funder referenceFunder name
096919Wellcome Trust
096919/Z/11/ZWellcome Trust